DDAVP

DDAVP is a synthetic ADH, or anti-diuretic hormone, drug with several uses. It can be used to decrease urine production and increase urine concentration in the treatment of central diabetes insipidus, a condition that causes the production of large amounts of diluted urine, or bedwetting. It is also common to use DDAVP for bleeding diseases such as hemophilia. DDAVP may also be used to counteract the effects of Plavix, an anti-coagulant drug. DDAVP medication is available in tablet, nasal spray, DDAVP melt, and injectable forms.

DDAVP side effects include minor ailments such as upset stomach, headache, and nasal side effects. The nasal side effects of nosebleed, sore throat, and congestion are more commonly reported when the DDAVP nasal spray is used. Major side effects such as seizures, increase in blood pressure, or serious allergic reactions are also possible.

DDAVP should be used with extreme caution in patients with Cystic Fibrosis and patients who also take medications to raise blood pressure. Patients with high blood pressure may need to be placed on a smaller dosage of DDAVP. Patients using DDAVP should also limit their fluid intake, in order to avoid a rare condition known as "water intoxication". Water intoxication is when a person takes in so much water that his or her blood develops decreased sodium levels, which can lead to seizures and even death. People who have a medical condition that can decrease blood sodium levels should also not take DDAVP. Some examples of such conditions are bulimia, anorexia, or adrenal disorders. Pregnant or nursing women should not take DDAVP without consulting their doctor.

When used to treat bedwetting in children, DDAVP has quick success. However, it does not work in cases where the bedwetting is caused by the child's failure to awaken when his or her bladder reaches capacity. If the child does not awaken, involuntary urination will occur. DDAVP's success in bedwetting treatment is because it decreases nighttime urine output only. DDAVP melt is a new form of DDAVP which is taken under the tongue and allowed to dissolve. This form of DDAVP takes about an hour to take effect, and the effects last 7 to 9 hours. This form is ideal for children who may have trouble with tablets or nasal sprays.

If too much DDAVP is taken, the only treatment is to reduce or stop the dosage altogether. There is no treatment that can reverse the effects of DDAVP, so patients must carefully follow their doctor's dosage instructions. Contact your doctor immediately if you feel you have overdosed or experience severe side effects.